Reactive perforating collagenosis is a very rare skin disorder whereby there is an elimination of altered protein substance (called collagen) through the layer of skin (called epidermis). The two distinct forms are an inherited form that manifests in childhood and an acquired form that occurs in adulthood.

Only a few cases have been reported in the medical literature. At Homeopathic Consultant, we have had a chance to record, treat and document such a case. (One case is not enough, though.)

It is also called the itching of renal failure, since it is very commonly seen in diabetic patients with renal failure on prolonged dialysis.

The major abnormality is focal damage to collagen followed by the elimination of the disrupted collagen through the epidermis. Cold or superficial blunt trauma often precipitates the lesions, especially in the inherited form. The acquired form usually occurs in patients with diabetes or chronic renal failure, especially those receiving dialysis. Acquired perforating collagenosis is more common, occurring in as many as 10% of patients receiving maintenance hemodialysis.

The lesions are intensely itchy, leaving some scarring after resolution.

The inherited form usually presents in infancy or early childhood. The acquired form occurs in adults.